Your doctor will examine you for TB and perform a test to see if you have TB. If your doctor feels that you are at risk for TB, you may be treated with medicine for TB before you begin treatment with SIMPONI ® and during treatment with SIMPONI ® . Even if your TB test is negative, your doctor should carefully monitor you for TB infections while you are taking SIMPONI ® . People who had a negative TB skin test before receiving SIMPONI ® have developed active TB. Tell your doctor if you have any of the following symptoms while taking or after taking SIMPONI ® :
Immunomodulators include medications such as 6-mercaptopurine and azathioprine. These are taken in pill form and absorbed into the bloodstream. They are effective for maintenance of remission in moderate to severe ulcerative colitis, but are slow to work and can take up to 2-3 months to reach their peak effect. Because of this, these medications are often combined with other medications (such as steroids) in patients who are very ill. These medications require frequent blood work, as they can cause liver test abnormalities and low white blood cell counts, both of which are reversible when the medication is stopped. Adverse reactions can include nausea, rash, liver and bone marrow toxicity, pancreatitis, and, rarely, lymphoma.