Strictly following the 4 R Protocol is imperative to eliminate IBS symptoms and help rebuild a healthy digestive tract, particularly if you have Leaky Gut symptoms. At least for a period of time, include therapeutic supplements that can help you get back on track. This is important - healing is impossible without removing the provocateurs, but removing them alone may not necessarily give your body what it needs to rebuild the digestive tract. The herbs referenced above for Leaky Gut smptoms will prove therapeutic for IBS as well. Adding additional magnesium to the diet is important with IBS (very effective for IBS with constipation, use caution in IBS with diarrhea). Eating magnesium in dark leafy greens will be a great source, but additional supplementation may be needed, particularly with constipation. Since IBS is so closely linked to the brain, you may want to replentish serotinin levels with 5-HTP , a precursor to serotonin.
Cortisol , a glucocorticoid, binds the glucocorticoid receptor. However, because of its molecular similarity to aldosterone it is also capable of binding the mineralcorticoid receptor. Both aldosterone and cortisol have a similar affinity for the mineralocorticoid receptor; however, there is vastly more cortisol in circulation than aldosterone. To prevent over-stimulation of the mineralocorticoid receptor by cortisol, 11β-HSD converts the biologically active cortisol to the inactive cortisone, which can no longer bind to the mineralocorticoid receptor. 11β-HSD co-localizes with intracellular adrenal steroid receptors. Licorice , which contains glycyrrhetinic acid , or enoxolone , can inhibit 11β-HSD and lead to a mineralocorticoid excess syndrome .
Cardiac glycosides: Licorice may potentiate toxicity (24) .
Diuretics : Licorice may increase the risk of hypokalemia (17) (18) .
Insulin: Licorice may increase insulin sensitivity (38) .
Anticoagulants: Licorice may increase the metabolism and clearance of warfarin (19) .
MAO-inhibitors (MAOIs): Licorice may potentiate activity of MAOIs (37)
P-Glycoprotein (P-gp) substrates: Licorice inhibited P-gp, resulting in increased intracellular concentration of the chemotherapy agent daunorubicin, which is a substrate of P-gp (34) .
Cytochrome P450 substrates: Glycyrrhizin, a major constituent of licorice, induces CYP3A (39) and CYP2D6 (44) , and can affect the intracellular concentration of drugs metabolized by this enzyme. However, other constituents, like glabridin, glycycoumarin and licochalcone A from different species of licorice can inhibit these enzymes (40) .
Cyclosporine: Licorice greatly reduced the oral bioavailability of cyclosporine by activating P-gp and CYP3A4 (46) .
Cortisol acetate: Licorice increased cortisol availability in tissues in the hours following oral cortisone acetate administration (47) .
Metformin: Pre-administration of licorice juice reduced the efficacy of metformin, in a rat model (58) . The clinical relevance in humans has yet to be determined.