For acne cysts on the face, it is safer to use 1 to 2 mg/mL to make sure that atrophy does not occur. On the trunk consider using 2 to mg/mL of triamcinolone. Enough suspension should be injected to see and feel the cyst become distended, but no more than mL is needed for any one cyst. One injection site per acne cyst should be adequate. If the cyst is large and soft, do not inject more volume because that can lead to atrophy. If there is a lot of purulent material inside the cyst, a quick incision and drainage (with lidocaine and a No. 11 scalpel) before injecting the steroid may be helpful.
Following each of two intralesional administrations, separated by 24 hours, of XIAFLEX mg into the penile plaque of 19 subjects with Peyronie’s disease, plasma levels of AUX-I and AUX-II in subjects with quantifiable levels (79% and 40% for AUX-I and AUX-II, respectively) were minimal and short-lived. The maximal plasma concentrations of AUX-I and AUX-II were <29 ng/mL and <71 ng/mL, respectively, and were observed approximately within 10 minutes after injection. All plasma levels were below the limits of quantification within 30 minutes following dosing. There was no evidence of accumulation following two sequential injections of XIAFLEX administered 24 hours apart. No subject had quantifiable plasma levels 15 minutes after modeling of plaque on Day 3 (., 24 hours after Injection 2 on Day 2).