Work from the laboratory of the late Professor Mike Rennie showed that stimulation of myofibrillar MPS was less for older adults than young with the ingestion of essential amino acids up to a dose of 20 g - equivalent to roughly 40 g of intact protein (Cuthbertson et al., 2005). We subsequently compiled data from several studies to garner information on the response to a single dose ingestion relative to total and lean body mass in young and older adults under resting conditions (Moore et al., 2015). The findings were consistent with the concept of anabolic resistance and the differences between young and older adults were marked when examined relative to lean body mass. The point where no further increase in MPS occurred with increasing protein ingestion was g and g protein/kg lean body mass for older and young adults, respectively. When considered in terms of total body mass, the response of MPS plateaued at ~ g protein/kg total body mass in older men and g protein/kg total body mass in young men. It is interesting to note that consuming g protein in each of three meals in a day would result in a total ingestion of g protein/kg for the day. This is the same amount that was associated with greater retention of lean body mass by older men (Houston et al., 2008). However, these results were measured under resting conditions. Since exercise, particularly resistance exercise, has a profound influence on the response of MPS to protein ingestion for up to 24 h following exercise (Burd et al., 2011), it is important to examine the single meal dose relationship of MPS following exercise.